Q:

A woman who is on regular COCP presented to you for advice on what to do as she has to now start to take a course of 7d antibiotics. What would you advice?

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A woman who is on regular COCP presented to you for advice on what to do as she has to now start to take a course of 7d antibiotics. What would you advice?


  1. Continue regular COC
  2. Continue COCP and backup contraception using condoms for 2d
  3. Continue COCP and backup contraception using condoms for 7d
  4. Continue COCP and backup contraception using condoms for 2wks

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The key is A. Continue regular COCP. [Before it was thought that antibiotics alter the gut flora and ethinyloestradiol is not conjugated. There is more ethinyloestradiol passed in the stool. So pregnancy and breakthrough bleeding can occur. But later it was established that the changes of gut flora is usually negligible for COCP conjugation to occur and hepatic enzyme induction may be more relavant reason. But it was also proved that for strong enzyme inducer like Rifampicin and Rifabutin there may need extra protection but other antibiotics practically does not reduce potency of COCP and hence except only drug like rifampicin or rifabutin for other antibiotics no additional precautions are needed].

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