Q:

An asymptomatic 56 year old man who has never consumed alcohol came for a routine checkup. Exam: increased skin pigmentation, spider angioma, cardiomegaly, S3 gallop, liver firm with 8cm span, no ascites. He is in the risk of which condition?

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An asymptomatic 56 year old man who has never consumed alcohol came for a routine checkup. Exam: increased skin pigmentation, spider angioma, cardiomegaly, S3 gallop, liver firm with 8cm span, no ascites. He is in the risk of which condition?


  1. Cerebellar degeneration
  2. Werniecke’s encephalopathy
  3. Renal failure
  4. Hepatoma
  5. Hepatic vein thrombosis

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The key is D. Hepatoma. [Increased skin pigmentation, features of chronic liver disease (spider angioma), Cardiomyopathy (cardiomegaly, S3 gallop), Enlarged liver these are suggestive of Haemochromatosis. (OHCM: Slate-grey skin pigmentation; signs of chronic liver disease; hepatomegaly; cirrhosis; dilated cardiomyopathy; osteoporosis; also endocrinopathies are features of haemochromatosis). If cirrhosis, 22–30% gethepatocellular cancer].

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