Q:

A 32 year old female with axillary freckles and café au lait spots wants to know the chances of her child also having similar condition

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A 32 year old female with axillary freckles and café au lait spots wants to know the chances of her child also having similar condition.


  1. 1:2
  2. 1:4
  3. No genetic link
  4. 1:16
  5. Depends on the genetic make up of the partner

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The key is E. Depends on genetic make up of the partner. [Depends on the make up of the partner, ideally it's 1:2 since it's autosomal dominant with complete penetrance but if the patients spouse also has neurofibromatosis, it raises it to at least 75% with a possible 100%].

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