Q:

A patient with hepatocellular carcinoma has raised levels of ferritin. What is the most probable cause?

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patient with hepatocellular carcinoma has raised levels of ferritin. What is the most probable cause?


  1. Hemochromatosis
  2. A1 antitrypsin def
  3. Cystic fibrosis

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The key is A. Haemochromatosis. [Hemochromatosis itself is a cause of hepatocellular carcinoma and associated with raised level of ferritin. Serum ferritin levels elevated higher than 200 mcg/L in premenopausal women and 300 mcg/L in men and postmenopausal women indicate primary iron overload due to hemochromatosis, especially when associated with high transferrin saturation and evidence of liver disease. Ferritin concentration higher than 1000 mcg/L suggests liver damage with n fibrosis or cirrhosis].

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