Q:

A 35 year old lady presents with painful ulcers on her vulva, what is the appropriate investigation which will lead to the diagnosis?

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A 35 year old lady presents with painful ulcers on her vulva, what is the appropriate investigation which will lead to the diagnosis?


  1. Anti-HSV antibodies
  2. Dark ground microscopy of the ulcer
  3. Treponema palladium antibody test
  4. Rapid plasma regain test
  5. VDRL

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The key is A. Anti-HSV antibodies. [Genital Herpes may be asymptomatic or may remain dormant for months or even years. When symptoms occur soon after a person is infected, they tend to be severe. They may start as multiple small blisters that eventually break open and produce raw, painful sores that scab and heal over within a few weeks. The blisters and sores may be accompanied by flu-like symptoms with fever and swollen lymph nodes. There are three major drugs commonly used to treat genital herpes symptoms: acyclovir (Zovirax), famciclovir (Famvir), and valacyclovir(Valtrex). These are all taken in pill form. Severe cases may be treated with the intravenous (IV) drug acyclovir].

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