A 45 year old woman presents with pruritis. Examination: skin pigmentation. Investigation: raised ALP and presence of anti-mitochondrial antibodies. What is the single most likely diagnosis?

The key is F. Primary biliary cirrhosis. [Primary biliary cirrhosis, is an autoimmune disease of the liver. It results from a slow, progressive destruction of the small bile ducts of the liver, causing bile and other toxins to build up in the liver, a condition called cholestasis. Further slow damage to the liver tissue leads to scarring, fibrosis, and eventually cirrhosis.Pruritus, skin pigmentation (increased amounts of melanin, widely dispersed throughout both epidermis and dermis), raised ALP, and presence of AMA are diagnostic of primary biliary cirrhosis].