Q:

A 65 year old woman complaining of symptoms suggestive of Raynaud’s phenomenon and difficulty in swallowing. Exam: painful lesions on her finger tips and facial telangiectasis. What is the single most likely positive antibody?

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A 65 year old woman complaining of symptoms suggestive of Raynaud’s phenomenon and difficulty in swallowing. Exam: painful lesions on her finger tips and facial telangiectasis. What is the single most likely positive antibody?


  1. Anti Jo1
  2. Anti Scl 70
  3. Anti Ro
  4. Anti ds DNA
  5. Anti centromere

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The key is E. Anti centromere. [Dysphagia, Raynaud’s phenomenon, telangtectasia, painful lesions

on fingertips these are suggestive features of CREST syndrome or limited scleroderma].

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