A 50 year old woman complains of several months history of weakness and difficulty climbing stairs. Examination: fissuring of the skin of her hands. CXR: pulmonary fibrosis. What is the single most likely positive antibody?
belongs to book: 1700 MCQ REVISED VERSION TOPIC WISE|DR. KHALID SAIFULLAH|4th EDITION| Chapter number:9| Question number:28
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Medicine
A. Anti Jo1. [Anticentromere would be present in limited scleroderma and Anti-Scl 70 would be
present in diffuse scleroderma. Anti-DSDNA would be positive in SLE, along with Anti-Ro. Anti-Ro is also
positive in Sjogren’s syndrome and scleroderma. This is a case of Polymyositis because none of the
others would have the muscular weakness that is present in this case. The antibody of choice in
polymyositis is Anti Jo1 antibody].
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