Q:

A 32 year old woman presents with malaise fatigue and fever. She complains about weight loss. Exam: malar rash with sparing of nasolabial fold can be seen. What is the most appropriate investigation?

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A 32 year old woman presents with malaise fatigue and fever. She complains about weight loss. Exam: malar rash with sparing of nasolabial fold can be seen. What is the most appropriate investigation?


  1. Anti ds DNA
  2. Anti histone
  3. Anti centromere
  4. Anti Jo
  5. Anti Scl70

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The key is A. Anti ds DNA. [Features are suggestive of SLE. So most appropriate investigation from

the given options is A. Anti ds DNA].

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