Q:

A 35 year old woman undergoing treatment for TB presents with malar rash, photosensitivity and hematuria. What is the single most likely positive antibody?

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A 35 year old woman undergoing treatment for TB presents with malar rash, photosensitivity and hematuria. What is the single most likely positive antibody?


  1. Anti Ds DNA
  2. Anti Sm
  3. Anti Histone
  4. Anti La
  5. Anti centromere

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The key is C. Antihistone antibody. [Anti histone antibody is present in 95% cases of drug induced

lupus. The most common drugs that cause drug-induced SLE are hydralazine (rate roughly 20%),

procainamide (rate roughly 20%, 5-8% if taken for 1 y), quinidine, isoniazid, and minocycline].

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