Patient with puffiness of face and rash showing cotton wool spots on fundoscopy. What’s the diagnosis?

The key is E. SLE. [Systemic lupus erythematosus (SLE) is an autoimmune disease. In this disease,

the immune system of the body mistakenly attacks healthy tissue. It can affect the skin, joints, kidneys,

brain, and other organs. Photosensitive butterfly erythematous rash on face (malar rash) and

arthropathy are most common feature. Here puffiness of face is due to lupus nephritis. The classic

ocular lesion in SLE is a white fluffy appearing lesion within the retina known as a cotton wool spot. The

most common ocular manifestation in SLE is Keratoconjunctivits sicca].