Q:

A 28 year old man presents with a maculopapular rash over his trunk and palms. He also has numerous mouth ulcers. He had a penile ulcer which healed 2wks ago. What will you do to confirm the diagnosis?

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A 28 year old man presents with a maculopapular rash over his trunk and palms. He also has numerous mouth ulcers. He had a penile ulcer which healed 2wks ago. What will you do to confirm the diagnosis?


  1. PCR for treponemal and non-treponemal antibiodies
  2. Dark ground microscopy from mouth ulcer
  3. Blood culture for treponema
  4. Dengue fever

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The key is A. PCR for treponomal and non-treponemal antibodies. [Non treponemal antibody test if

positive indicate that there may be syphilis and it is not confirmatory alone. That is why treponemal

antibody test should also be done to confirm it. On the other hand resolved disease may show negative

treponemal test which is confirmed by positive non-treponemal test].

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