Q:

A young boy presented to the OPD 12 weeks after renal transplantation with fever and pain in lower abdomen. Renal functions were deranged. Renal biopsy showed immune cell infiltrate and tubular damage. What is the most probable dx?

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A young boy presented to the OPD 12 weeks after renal transplantation with fever and pain in lower abdomen. Renal functions were deranged. Renal biopsy showed immune cell infiltrate and tubular damage. What is the most probable dx?


  1. Pyelonephritis
  2. Chronic graft rejection
  3. Acute rejection
  4. Drug toxicity
  5. Graft vs host disease

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The key is C. Acute rejection. [Acute rejection usually occurs in the first few months after

transplant, but may occur up to a year after transplant. Rise of creatinine, fever, graft pain these may be

seen in acute graft rejection. Biopsy showing immune cell infiltrate and tubular damage are suggestive

of acute graft rejection].

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