Q:

A 44 year old man presents with periorbital and pedal edema. 24h urine shows 8g of protein/d and serum cholesterol 7mmol/L. Renal biopsy results are awaited. What would be the most likely diagnosis?

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A 44 year old man presents with periorbital and pedal edema. 24h urine shows 8g of protein/d and serum cholesterol 7mmol/L. Renal biopsy results are awaited. What would be the most likely diagnosis? 


  1. Minimal change disease
  2. Glomerulonephropathy
  3. Membranous glomerulonephropathy
  4. FSGS
  5. IgA nephropathy
  6. Mesangiocapillary

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The given key is C. Membranous glomerulonephritis. [This is nephrotic syndrome. It is characterized by proteinuria more than 3gm/24hours, low albumin, edema and high cholesterol. Most common causes of nephrotic syndrome in adults are membranous glomerulonephropathy and FSGS (focal segmental glomerulosclerosis)].  

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