Q:

A 34 year old African-caribbean man with a history of sarcoidosis has presented with bilateral kidney stones. What is the most likely cause for this patient’s stones?

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A 34 year old African-caribbean man with a history of sarcoidosis has presented with bilateral kidney stones. What is the most likely cause for this patient’s stones? 


  1. Hypercalcemia
  2. Hyperuricemia
  3. Diet
  4. Recurrent UTIs
  5. Hyperparathyroidism

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The key is A. Hypercalcemia. [Hypercalcemia in sarcoidosis is due to the uncontrolled synthesis of 1,25-dihydroxyvitamin D3 by macrophages. 1,25-dihydroxyvitamin D3 leads to an increased absorption of calcium in the intestine and to an increased resorption of calcium in the bone]. 

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