Q:

A 36 year old woman presented with massive bleeding from multiple sites. Laboratory investigations: fibrin degradation products: +++, plt 30, bleeding time prolonged, PT prolonged, APTT prolonged. What is the most likely diagnosis?

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A 36 year old woman presented with massive bleeding from multiple sites. Laboratory investigations: fibrin degradation products: +++, plt 30, bleeding time prolonged, PT prolonged, APTT prolonged. What is the most likely diagnosis? 


  1. Hemophilia
  2. DIC
  3. ITP
  4. Factor V leiden
  5. Warfarin

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The key is B. DIC. [Disseminated intravascular coagulation (DIC) is characterized by systemic activation of blood coagulation, which results in generation and deposition of fibrin, leading to microvascular thrombi in various organs and contributing to multiple organ dysfunction syndrome (MODS). Consumption of clotting factors and platelets in DIC can result in life-threatening hemorrhage. Usual lab reports are i) Platelets: Typically, moderate-to-severe thrombocytopenia is present in DIC. ii) Bleeding time prolonged iii) Global clotting times: (ie, activated partial thromboplastin time [aPTT] and prothrombin time [PT]) are typically prolonged. iv) Assay for D-dimer or FDPs: elevated]. 

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