Q:

A 57 year old man presents with weight loss, tiredness, fever and abdominal discomfort. Exam: spleen palpable up to the umbilicus. Labs: WBC=127, Hgb=8.7, Plt=138. What is the most likely diagnosis?

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A 57 year old man presents with weight loss, tiredness, fever and abdominal discomfort. Exam: spleen palpable up to the umbilicus. Labs: WBC=127, Hgb=8.7, Plt=138. What is the most likely diagnosis?


  1. CML
  2. AML
  3. CLL
  4. AML
  5. Polycythemia

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The key is A. CML. [Points in favour of CML: i) Age 57 years ii) weight loss iii) abdominal discomfort iv) anaemia v) fever vi) marked splenomegaly and high WBC count].

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