Q:

A 74 year old female presents with headache and neck stiffness to the emergency department. Following a LP the patient was started on IV ceftriaxone. CSF culture revealed listeria monocytogenes. What is the appropriate treatment?

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A 74 year old female presents with headache and neck stiffness to the emergency department.

Following a LP the patient was started on IV ceftriaxone. CSF culture revealed listeria

monocytogenes. What is the appropriate treatment?


  1. Add IV amoxicillin
  2. Change to IV amoxicillin + gentamicin
  3. Add IV ciprofloxacin
  4. Add IV co-amoxiclav
  5. Continue IV ceftriaxone as mono-therapy

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The key is B. Change to IV amoxicillin + gentamycin. [From the given option B is the most

acceptable. However Ampicillin + gentamycin is the drug combination of choice].

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