Q:

A 60 year old DM patient presented with easy fatigability, weakness and numbness of hands and Urine: proteinuria. US abdomen: enlarged kidney. Renal biopsy: amorphous homogenous substance that stained red with congo-red. What is the diagnosis?

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A 60 year old DM patient presented with easy fatigability, weakness and numbness of hands and

swollen feet. Examination: pedal edema, sensory neuropathy and palpable liver and spleen.

Urine: proteinuria. US abdomen: enlarged kidney. Renal biopsy: amorphous homogenous

substance that stained red with congo-red. What is the diagnosis?

 


  1. DM retinopathy
  2. Sarcoidosis
  3. Wilms tumor
  4. Amyloidosis
  5. Glycogen storage disease

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The key is D. Amyloidosis [Islet amyloid is a characteristic pathological finding in patients with type

2 diabetes mellitus, being present in more than 90 percent. Amyloidosis is a common cause of

organomegaly. Also in diabetic nephropathy kidneys may be enlarged].

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