Q:

A 34 year old woman presents with truncal obesity, easy bruising, hyperglycemia, high BP and depression. Which of the following investigation will be most helpful in localizing the cause for Cushing’s syndrome?

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A 34 year old woman presents with truncal obesity, easy bruising, hyperglycemia, high BP and

depression. Which of the following investigation will be most helpful in localizing the cause for

Cushing’s syndrome?


  1. Serum cortisol
  2. 24h urinary cortisol
  3. Low dose dexamethasone suppression test
  4. High dose dexamethasone suppression test
  5. Overnight dexamethasone suppression test

All Answers

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The key is D. High dose dexamethasone suppression test. [High dose dexamethasone suppression

test can identify whether pituitary adenoma or ectopic ACTH producing tumour. Suppression is absent in

patients with Cushing syndrome due to ectopic ACTH secretion or adrenal abnormalities. Suppression is

present in patients with Cushing disease].

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