Q:

A young woman complains of diarrhea, abdominal cramps and mouth ulcers. Abdominal X-ray shows distended transverse colon with globet cell depletion on rectal biopsy. What is the most probable diagnosis?

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A young woman complains of diarrhea, abdominal cramps and mouth ulcers. Abdominal X-ray shows distended transverse colon with globet cell depletion on rectal biopsy. What is the most probable diagnosis?


  1. CD (Crohn’s disease)
  2. UC (Ulcerative colitis)
  3. Bowel Ca
  4. Bowel obstruction
  5. IBS (Irritable bowel syndrome)

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The key is B. UC. [In UC there is goblet cell depletion and less mucous production in contrast with CD where there may be goblet cell hyperplasia and mucous secretion is not reduced. Please note aphthous ulcer can develop in both CD and UC].

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