Q:

A 35 year old man presents with history of dyspepsia. H.Pylori antibodies are negative. No improvement is seen after 1m of treatment. What is the next step?

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A 35 year old man presents with history of dyspepsia. H.Pylori antibodies are negative. No improvement is seen after 1m of treatment. What is the next step?


  1. Urea breath test
  2. Gastroscopy
  3. CT
  4. MRI

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The key is B. Gastroscopy. [Not responding to treatment D/D is: i) Jollinger Elison syndrome ii) Ca stomach. Indications of gastroscopy in a 35 yo man (for man of age <50): i) Acute symptoms with H/O previous episode (PUD) ii) Alarm features [weight loss, anaemia, vomiting, hematemesis and melaena, dysphagia, palpable abdominal mass], fear of cancer, evidence of organic disease].

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