Q:

When an action potential arrives at a synapse, what happens fi rst?

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When an action potential arrives at a synapse, what happens fi rst?


  1. a neurotransmitter is released into the synaptic cleft
  2. extracellular Na + crosses the post-synaptic membrane
  3. Choline in the synaptic cleft enters the nerve cell and is converted to acetyl choline
  4. extracellular Ca ++ enters the nerve cell

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D: As the axon terminal depolarises when the action potential arrives, calcium channels open and extracellular calcium enters the axon terminal. This stimulates the release of a neurotransmitter (e.g. ACh) into the synaptic cleft.  

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