Q:

Which molecule or ion dissolved in blood is able to stimulate the central chemoreceptors of the brain’s respiratory centre?

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Which molecule or ion dissolved in blood is able to stimulate the central chemoreceptors of the brain’s respiratory centre?


  1. CO 2
  2. H 3 O +
  3. O 2
  4. Ca ++

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A: Blood borne hydronium cannot cross the blood-brain barrier. However carbon dioxide can and it produces hydronium ions when it is on the brain side of the BBB. As there is no buffer in the CSF, these hydronium ions stimulate the central chemoreceptors of the respiratory centre. 

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