Q:

Why is insulin not given as an oral drug

0

Why is insulin not given as an oral drug?


  1. It is too irritating to the gastro-intestinal mucosa
  2. It is altered by passing through the liver
  3. It is too big a molecule to be absorbed through the plasma membrane
  4. It would be digested by enzymes in the stomach

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D: Insulin is a protein so would be hydrolysed by protein digesting enzymes in the stomach (and duodenum). 

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