Q:

A 15- year- old boy with rheumatoid arthritis, on quinine for 6 months, presented With fever, aphthous stomatitis, and fatigue for the last 5days. His absolute neutrophil count (ANC)was 700/uL

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 A  15- year- old boy with  rheumatoid arthritis, on quinine  for 6 months, presented With fever,  aphthous stomatitis, and fatigue for the last 5days. His absolute neutrophil count  (ANC)was 700/uL

 The MOST next appropriate therapeutic measure to be done when quinine withdrawal fails to irnprove neutropenia is


  1. administration of MG
  2. aggressive use of antibiotics
  3. transplantation of hematopoietic stem cells
  4. administration of pulse methylprednisolone
  5. administration of recombinant human granulocyte colony- stimulating factor

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