Q:

All the following drugs can induce neutropenia EXCEPT

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All the following drugs can induce neutropenia EXCEPT


  1. penicillin
  2. tetracycline
  3. phenobarbital
  4. phenothiazine
  5. chloramphenicol

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(B). The process of neutropenia likely arises from effects of drugs, such as propylthiouracil or penicillin, that act as haptens to stimulate antibody formation, or drugs, such as quinine, that induce immune complex formation. Late-onset neutropenia can occur after rituximab therapy. Idiosyncratic reactions, for example to chloramphenicol, are unpredictable with regard to dose or duration of use. Hypersensitivity reactions are rare and may involve arene oxide metabolites of aromatic anticonvulsants (phenytoin or phenobarbital). 

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