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A 3-year-old girl presented with recurrent attacks of chest infection and frequent episodes of chronic diarrhea, stool examination revealed Giardia lamblia and serum IgA level was very low

safaTerkawi
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2022-09-15
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A 3-year-old girl presented with recurrent attacks of chest infection and frequent episodes of chronic diarrhea, stool examination revealed Giardia lamblia and serum IgA level was very low.

Regarding this condition, all the following are true EXCEPT  

  1. autosomal dominant inheritance
  2. phenotypically normal blood B cells
  3. administration of IVIG is not indicated
  4. environmental factors may trigger the disease
  5. it is associated with a celiac-like syndrome with dramatic response to gluten-free diet
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safaTerkawi
2022-09-15
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(E). An isolated absence or near absence (<10 mg/dl.) of serum and secretory lgA is the most common well-defined immunodeficiencydisorder. lgA deficiency is associated with a celiac-likesyndrome,which may or may not respond to a gluten-free diet.

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