In X-linked adrenoleukodystrophy (ALD),MRI shows characteristic cerebral white matter lesions mainly in

(D). In 80% of patients, the lesions are symmetric and involve the periventricular white matter in the posterior parietal and occipital lobes. Approximately 50% show a garland of accumulated contrast material adjacent and anterior to the posterior hypodense lesions. In 12% of patients, the initial lesions are frontal.