Q:

All the following are recognized feature of Niemann-pick disease type B EXCEPT

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All the following are recognized feature of Niemann-pick disease type B EXCEPT


  1. normal IQ
  2. progressive lung disease
  3. prolonged neonatal jaundice
  4. subtle or no neurologic involvement
  5. cherry-red maculae in some patients

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(C). Niemann-pick disease type B patients do not have neurologic involvement and have a normal IQ. Some patients with type B disease have cherry-red maculae or haloes and subtle neurologic symptoms(peripheral neuropathy). In some type B patients, decreased pulmonary diffusion caused by alveolar infiltration becomes evident in late childhood or early adulthood and progresses with age. Prolonged neonatal jaundice occurs in type  C

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