A 9-year-old boy admintted to the hospital because of fracture of left femur due to a minor trauma

(C). Treatment of patients with Gaucher disease type 1 includes enzyme replacement therapy. The efficacy of enzyme replacement therapy with mannose-terminated recombinant human acid B-glucosidase has definitively been demonstrated. Most symptoms (organomegaly, hematologic indices, bone pain) are reversed by enzyme replacement therapy (60 IU/kg) administered by intravenous infusion every other week and the bone involvement can be stabilized or improved