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A 4-year-old female child, a known case of ALL

Anwaar
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2022-09-11
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A 4-year-old female child, a known case of ALL, she is developing an increasing toxicity to methotrexate therapy. Of the following, the MOST useful test is

  1. homocysteine level
  2. prothrombin test
  3. factor V lelden
  4. MTHFR DNA testing
  5. folate level
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Anwaar
2022-09-11
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(D). Knowledge of individual genotypes (pharmacogentic genetic testing) will guide pharmacologic therapy, allowing customization of choice of drug and dosage to avoid toxicity and provide a therapeutic response. An example of this is testing for polymorphisms within the methylenetetrahydrofolate reductase (MTHFR) gene for susceptibility of potentially increased toxicity to methotrexate antimetabolite therapy for treatment of acute lymphoblastic leukemia.

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