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Cardiovascular (CV) and CNS symptoms dominate the clinical presentation of tricyclic antidepressant (TCA) toxiciy

Anwaar
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2022-09-10
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Cardiovascular (CV) and CNS symptoms dominate the clinical presentation of tricyclic antidepressant (TCA) toxiciy, symptoms typically develop within1-2 hr of ingestion, and serious toxicity usually manifests within 6 hr of ingestion. Of the following, the MOST common CV manifestation is

  1. hypotension
  2. sinus tachycardia
  3. widened QRS interval
  4. ventricular arrhythmias
  5. prominent R wave in lead aVR
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Anwaar
2022-09-10
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(B). Sinus tachycardia is the most common cardiovascular manifestation of toxicity; however, patients can develop widening of the QRS complex, premature ventricular contractions, and ventricular arrhythmias. Refractory hypotension is a poor prognostic indicator and is the most common cause of death in TCA overdose.

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