Q:

In acetaminophen poisoning, when the initiation of N-Acetylcysteine therapy is delayed, there is the greater the risk of acute liver failure

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In acetaminophen poisoning, when the initiation of N-Acetylcysteine therapy is delayed, there is the greater the risk of acute liver failure. N-Acetylcysteine should be instituted no later than


  1. 2 hr after ingestion
  2. 4 hr after ingestion
  3. 6 hr after ingestion
  4. 8 hr after ingestion
  5. 10 hr after ingestion

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(D). The importance of instituting therapy with either IV or oral N-Acetylcysteine (NAC) no later than 8 hr from the time of ingestion cannot be overemphasized. No patient, no matter the size of the ingestion, who receives NAC within 8 hr of overdose, should die from liver failure. The further out from the 8 hr mark the initiation of therapy is delayed, the greater the risk of acute liver failure

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