In acetaminophen poisoning, when the initiation of N-Acetylcysteine therapy is delayed, there is the greater the risk of acute liver failure

(D). The importance of instituting therapy with either IV or oral N-Acetylcysteine (NAC) no later than 8 hr from the time of ingestion cannot be overemphasized. No patient, no matter the size of the ingestion, who receives NAC within 8 hr of overdose, should die from liver failure. The further out from the 8 hr mark the initiation of therapy is delayed, the greater the risk of acute liver failure