Alkalinization of urine is MOST useful in managing toxicity with

(C). Urinary alkalinization (UA) enhances the elimination of some drugs that are weak acids by forming charged particles that are "trapped" within the renal tubules and thus excreted. Urinary alkalinization is accomplished via a continuous infusion of sodium bicarbonate-containing intravenous fluids, with a goal urine pH of 7.5-8. Alkalinization of the urine is most useful in managing salicylate and methotrexate toxicity