Q:

A chromosomal study of 22-year-old mother of a baby with Down syndrome t (14; 21) shows that; she is the carrier for the translocation

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A chromosomal study of 22-year-old mother of a baby with Down syndrome t (14; 21) shows that; she is the carrier for the translocation, You explained thathe recurrence rate will be approximately


  1. 2-4%
  2. 5-7%
  3. 8-10%
  4. 11-13%
  5. 33%

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(B). Translocation (21; 21) carriers have a 100% recurrence risk for a chromosomally abnormal child, and other Robertsonian translocations, such as t(14;21), have a 5-7% recurrence risk when transmitted by females

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