For each substance A–E, select the best option for its functional description from the following list

A. Option 4 A ‘glucocorticoid’. Glucocorticoids promote protein catabolism, glucogenesis and gluconeogenesis.

B. Option 5 Causes breast development. Progesterone can be manufactured from pregnenolone in the adrenal cortex.

C. Option 1 A ‘mineralocorticoid’. Aldosterone promotes fluid retention by facilitating sodium retention by the renal tubules.

D. Option 3 An alpha globulin that binds with cortisol. Most circulating cortisol is bound to transcortin and is inactive. Cortisol is freed and becomes physiologically active when free cortisol levels fall.

E. Option 2 An androgen. This can cause ‘virilization’ in female patients with adrenocor-tical tumours.