Q:

The plasma level of adrenocorticotrophic hormone (ACTH)

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The plasma level of adrenocorticotrophic hormone (ACTH).


  1. Is normally maximal around midnight.
  2. Is regulated mainly by the blood cortisol level.
  3. Shows exaggerated circadian fluctuations with an adrenal tumour.
  4. Is raised in the presence of complete adrenal failure.
  5. Is reduced in patients on long-term high dosage glucocorticoids.

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A. False It is maximal around the time of awakening.

B. False This feedback system is over-ridden by the hypothalamic circadian rhythm.

C. False The level is high but the circadian rhythm is lost.

D. True Due to loss of negative feedback by cortisol.

E. True ACTH is suppressed by these exogenous glucocorticoids.

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