Cortisol

safaTerkawi

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2022-08-14

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Cortisol.

Is bound in the plasma to an alpha globulin.
Is inactivated in the liver and excreted in the bile.
Injections lead to a rise in arterial pressure.
Inhibits release of ACTH from the anterior pituitary gland.
Is released with a circadian variation so that cortisol blood levels peak in the morning.

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safaTerkawi

2022-08-14

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A. True It is bound to transcortin; free cortisol is released to replace that taken up by the tissues.

B. False The inactive products of cortisol degradation in the liver are conjugated with glucuronic acid and sulphate and excreted in the urine.

C. True Partly at least because of its mineralocorticoid effects.

D. True The negative feedback loop that maintains plasma cortisol levels constant.

E. True It is regulated through a hypothalamic ‘clock’.

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