Q:

A patient with chronic respiratory failure

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 A patient with chronic respiratory failure.


  1. Shows an enhanced respiratory sensitivity to inhaled carbon dioxide.
  2. Shows little or no respiratory response to hypoxia.
  3. Is likely to have a low blood bicarbonate level.
  4. Responds well when given 100 per cent oxygen to breathe.
  5. Must have been breathing oxygen-enriched air if alveolar PCO2 is 150 mmHg (20 kPa).

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A. False There is increased tolerance of high PCO2 levels.

B. False Sensitivity to low PO2 remains and is important in maintaining ventilation.

C. False HCO3- levels rise to compensate for the raised PCO2 in respiratory acidosis.

D. False This could arrest ventilation by removing hypoxic drive; 24–28 per cent O2 would do.

E. True When breathing air, PO2+PCO2 equal about 140 mmHg (19 kPa).

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