Narrowing of the lumen of major arteries supplying the leg is associated with

A. True  This is ‘intermittent claudication’; pain metabolites accumulate in muscle during exercise in ischaemic limbs and stimulate local pain receptors.

B. True  When the major arteries are obstructed, collateral vessels open up to help maintain blood flow to the ischaemic tissues.

C. False  Though the hyperaemias have smaller peak values, their durations are longer.

D. True  Cuts and ulcers are slow to heal because the supply of nutrients is impaired.

E. True  Pulses may be absent with severe narrowing.