Q:

Vitamin B12 deficiency may

safaTerkawi
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2022-08-07
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 Vitamin B12 deficiency may.

  1. Result from disease of the terminal part of the ileum.
  2. Result in anaemia with small RBCs well filled with haemoglobin.
  3. Cause wasting (atrophy) of the gastric mucosa.
  4. Cause a reduction in the circulating platelet level.
  5. Cause pathological changes in the central nervous system.
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safaTerkawi
2022-08-07
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A. True  The B12/intrinsic factor complex is absorbed in the terminal ileum.

B. False  Lack of B12 results in a macrocytic hyperchromic anaemia.

C. False  Gastric mucosa atrophy is a cause, not an effect, of B12 lack; gastric mucosa normally produces the ‘intrinsic factor’ required for B12 absorption.

D. True  B12 is used in the DNA synthesis required by platelet precursor cells.

E. True  Maintenance of myelin in neural sheaths also depends on vitamin B12.

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